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Updated: Feb 8, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Effects of pre-transplant azithromycin administration on kidney graft function: study protocol for a double-blind

Gholamreza Mokhtari1, Mojtaba Teimoori2,3

  • 1Transplant surgeon, Urology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran.

Trials
|June 29, 2018
PubMed
Abstract

Insights

This study investigates azithromycin

Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • Kidney transplantation is optimal for end-stage renal disease but requires outcome improvement.
  • Macrolides, like azithromycin, possess anti-inflammatory properties and tissue accumulation potential.
  • Theoretical benefits include graft immunomodulation and improved kidney transplant outcomes.

Purpose of the Study:

  • To evaluate the efficacy of a single azithromycin dose in kidney donors.
  • To assess the impact of azithromycin on kidney graft function and post-transplant outcomes.
  • To explore azithromycin's role in reducing adverse events in kidney transplantation.

Main Methods:

  • Single-center, randomized clinical trial with 60 kidney donors.
  • Donors received a single 1g dose of azithromycin or placebo 1 day pre-surgery.
  • Outcomes assessed include graft function, rejection rates, infections, and donor/recipient complications.

Main Results:

  • This section is pending study completion and analysis.
  • Further data collection and analysis are ongoing.
  • The study aims to determine if azithromycin reduces adverse outcomes.

Conclusions:

  • Short and mid-term analyses of biological samples are planned.
  • Immunological assays will provide in-depth insights into azithromycin's effects.
  • Confirmation of efficacy could establish azithromycin as an accessible intervention to lower post-transplantation risks.
Keywords:
AzithromycinGraft rejectionImmunomodulationKidney transplantationTransplant recipients

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