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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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[Expression of Extracellular Matrix Protein Reelin in Patients with Multiple Myeloma and Its Relationship with

Quan-Ming An1, Yuan-Gen Liu1, Liang Lin1

  • 1Department of Immunology, Peking University Health Science Center, Beijing 100101,China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 29, 2018
PubMed
Abstract

Insights

High expression of Reelin (RELN) in multiple myeloma patients correlates with poorer prognosis and disease progression. This finding suggests RELN may be a valuable biomarker for predicting patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Multiple myeloma is a hematological malignancy characterized by uncontrolled proliferation of plasma cells.
  • Extracellular matrix proteins play crucial roles in tumor microenvironment and progression.
  • Reelin (RELN) is an extracellular matrix glycoprotein with known roles in neuronal development and tissue repair.

Purpose of the Study:

  • To investigate the expression of Reelin (RELN) in multiple myeloma patients.
  • To determine the relationship between RELN expression levels and patient prognosis.

Main Methods:

  • Mononuclear cells were isolated from bone marrow of multiple myeloma patients.
  • CD138+ plasma cells were purified using flow cytometry.
  • Messenger RNA (mRNA) levels of RELN were quantified using real-time PCR.
  • Statistical analysis correlated RELN expression with clinical data and survival outcomes.

Main Results:

  • High RELN expression significantly correlated with increased CD138+ cell percentage, reduced progression-free survival, and shorter overall survival.
  • RELN expression did not significantly correlate with Durie-Salmon (DS) or International Staging System (ISS) stages.
  • Patients with high RELN expression exhibited elevated serum M protein, uric acid, and calcium, lower hemoglobin, and more frequent chromosomal abnormalities (e.g., RB1 deletion, 1q21 amplification).

Conclusions:

  • Reelin (RELN) expression is significantly associated with disease progression in multiple myeloma.
  • RELN may serve as a prognostic biomarker for multiple myeloma patients.

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