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  11. Impact Of Characteristics Of Organ Failure And Infected Necrosis On Mortality In Necrotising Pancreatitis.

Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis.

Nicolien J Schepers1, Olaf J Bakker2, Marc G Besselink3

  • 1Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Gut
|June 29, 2018

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View abstract on PubMed

Summary
This summary is machine-generated.

In necrotising pancreatitis, early organ failure does not increase mortality risk. The timing and duration of organ failure showed no significant association with patient survival.

Area of Science:

  • Gastroenterology
  • Critical Care Medicine
  • Surgical Pathology

Background:

  • Necrotising pancreatitis poses a significant mortality risk, primarily attributed to early organ failure.
  • Understanding the temporal relationship between organ failure and outcomes is crucial for patient management.

Purpose of the Study:

  • To investigate the association between the timing (onset and duration) of organ failure and mortality in patients with necrotising pancreatitis.
  • To explore the impact of infected pancreatic necrosis on mortality in the context of organ failure.

Main Methods:

  • Post hoc analysis of a prospective database including 639 patients with necrotising pancreatitis.
  • Evaluation of organ failure onset, duration, and type (respiratory, cardiovascular, renal).
  • Statistical analysis to determine associations with mortality and infected pancreatic necrosis.
Keywords:
acute pancreatitisinflammationpancreas

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Main Results:

  • 38% of patients developed organ failure; 51% of these had onset in the first week with 42% mortality.
  • Mortality rates were similar for organ failure with or without infected pancreatic necrosis when excluding early deaths (within 10 days).
  • No significant association was found between the duration of organ failure and mortality.

Conclusions:

  • Early persistent organ failure in necrotising pancreatitis is not linked to increased mortality compared to later onset.
  • The duration of organ failure does not appear to be a significant predictor of mortality in this patient cohort.