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Updated: Feb 8, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
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Erdafitinib Efficacious in Bladder Cancer

    Cancer Discovery
    |June 29, 2018
    PubMed

    Insights

    Erdafitinib shows clinical efficacy in patients with advanced urothelial carcinoma harboring fibroblast growth factor receptor alterations. This pan-FGFR inhibitor demonstrated robust responses, even in patients previously unresponsive to immunotherapy.

    Area of Science:

    • Oncology
    • Medical Genetics

    Background:

    • Urothelial carcinoma is a significant cause of cancer mortality.
    • Fibroblast growth factor receptor (FGFR) alterations are implicated in urothelial carcinoma pathogenesis.
    • Targeted therapies offer a promising avenue for treatment.

    Discussion:

    • Erdafitinib, a pan-FGFR inhibitor, was investigated in a phase II study for advanced urothelial carcinoma.
    • The study assessed clinical efficacy and response rates in patients with FGFR alterations.
    • Prior treatment history, including immunotherapy response, was considered.

    Key Insights:

    • Erdafitinib demonstrated clinical efficacy in patients with FGFR-altered inoperable or metastatic urothelial carcinoma.
    • Robust treatment responses were observed with erdafitinib.
    • Efficacy was noted even in patients who had not responded to prior immunotherapy.

    Outlook:

    • Erdafitinib represents a potential therapeutic option for a specific subset of urothelial carcinoma patients.
    • Further investigation may explore its role in combination therapies or earlier lines of treatment.
    • Personalized medicine approaches targeting FGFR alterations are advancing cancer care.

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