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Human MxB Protein Is a Pan-herpesvirus Restriction Factor

Mirjam Schilling1, Lorenzo Bulli2, Sebastian Weigang1

  • 1Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany.

Journal of Virology
|June 29, 2018
PubMed
Summary

The human MX2 gene product MxB restricts herpesvirus replication, acting as a broad antiviral factor. This dynamin-like GTPase differs in its mechanism against herpesviruses compared to HIV-1.

Keywords:
HCMVHSV-1MHV68MxB proteincytomegalovirusherpes simplex virusherpesviruseshuman MX2 geneinnate immunityinterferons

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