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Updated: Feb 8, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
[Body weight and bone/calcium metabolism. Glucose-lowering agents and fracture risk.]
Reiko Watanabe1, Daisuke Inoue1
1Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
Abstract:
Diabetes is associated with increased fracture risk, involving a variety of factors. Besides poor glycemic control itself, some glucose-lowering agents are also associated with increased fracture risk. Thiazolidinediones increase fracture risk probably through inhibition of bone formation as well as increased resorption leading to decreased BMD. Sodium-glucose cotransporter(SGLT)-2 inhibitors have been reported to decrease BMD and increase fracture risk. However, the class effect of SGLT-2 inhibitors on bone metabolism remains to be established. In diabetic patients, especially in those with high fracture risk such as postmenopausal women, careful selection of glucose-lowering agents as well as appropriate and timely intervention for osteoporosis is necessary.
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