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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

Pleura of the Lungs

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Impedance Combination01:21

Impedance Combination

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Consider a string of christmas lights, each bulb symbolizing an impedance element. In this series configuration, the flow of electric current remains uniform across every component. This behavior aligns with Kirchhoff's Voltage Law (KVL), which asserts that the total impedance in such a setup equals the sum of individual impedances—akin to resistors in series. It follows that the voltage from the power source is distributed proportionally among these components, adhering to the voltage...
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Combination Of Resistors01:18

Combination Of Resistors

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Electrical devices in any circuit can be connected either by series or parallel connections. Additionally, circuits can be connected involving both of these connections, known as combination or complex circuits. As these circuits have complex resistor connections, it is necessary to identify different parts as either series or parallel connections, then the whole combination of series and parallel resistors can be reduced to a single equivalent resistance. With the known equivalent resistance...
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Combining Functions01:16

Combining Functions

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Functions can be combined to form new mathematical models that describe interactions between variables. These combinations are fundamental in understanding relationships between changing quantities and are commonly encountered in scientific and engineering contexts. The combination methods—addition, subtraction, multiplication, division, and composition—each have unique implications for the resulting function’s domain and behavior.When combining functions through arithmetic...
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Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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Combined small-cell lung carcinoma.

Jing Qin1,2, Hongyang Lu1,2

  • 1Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou 310022, People's Republic of China.

Oncotargets and Therapy
|June 29, 2018
PubMed
Summary
This summary is machine-generated.

Combined small-cell lung carcinoma (C-SCLC) research is limited. This review details C-SCLC

Keywords:
C-SCLCclinicalmolecular featurespathologicprognosistreatment

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Area of Science:

  • Oncology
  • Pulmonology
  • Pathology

Background:

  • Combined small-cell lung carcinoma (C-SCLC) is understudied, with limited data on its characteristics, treatment, and outcomes.
  • Incidence varies (5%-28%) based on specimen type.
  • C-SCLC often presents peripherally, at earlier stages, and is amenable to surgery.

Purpose of the Study:

  • To review the current literature on combined small-cell lung carcinoma (C-SCLC).
  • To elucidate clinicopathological features, prognostic factors, and treatment strategies for C-SCLC.
  • To identify areas for optimizing the treatment model for C-SCLC patients.

Main Methods:

  • Comprehensive literature review of studies on combined small-cell lung carcinoma (C-SCLC).
  • Analysis of clinicopathological data, treatment outcomes, and survival statistics.
  • Synthesis of information regarding prognostic indicators and therapeutic approaches.

Main Results:

  • C-SCLC exhibits distinct clinical features, including peripheral location and earlier stage at diagnosis.
  • Surgery is a critical treatment modality for early-stage C-SCLC.
  • Current chemotherapy regimens for SCLC show no significant survival benefit in C-SCLC; EGFR-TKI efficacy in EGFR-mutated C-SCLC is uncertain.

Conclusions:

  • Further research is needed to fully characterize combined small-cell lung carcinoma (C-SCLC).
  • Optimized treatment strategies, potentially including targeted therapies, require further investigation.
  • Establishing clear prognostic factors will aid in personalized C-SCLC management.