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Updated: Feb 8, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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Multiple biological functions of transcription factor 21 in the development of various cancers

Xiaodi Jiang1, Zhi Yang2

  • 1Department of Infectious Disease, The Shengjing Hospital of China Medical University, Shenyang, China.

Oncotargets and Therapy
|June 29, 2018
PubMed

Insights

Transcription factor 21 (TCF21) plays a crucial role in cell development and cancer. This review explores TCF21

Area of Science:

  • Molecular biology
  • Developmental biology
  • Cancer research

Background:

  • Transcription factor 21 (TCF21) is a basic helix-loop-helix protein.
  • TCF21 regulates cell differentiation and fate specification during development.
  • The TCF21 gene is epigenetically silenced in various human cancers.

Purpose of the Study:

  • To review research on the roles of TCF21 in tumor development.
  • To systematically analyze TCF21's pathological functions across different cancers.
  • To elucidate the molecular mechanisms underlying TCF21's diverse biological roles in cancer.

Main Methods:

  • Literature review of studies on TCF21 and cancer.
  • Systematic analysis of TCF21's functions in various cancer types.
  • Examination of molecular pathways regulated by TCF21.

Main Results:

  • TCF21 regulates epithelial-mesenchymal transition, invasion, and metastasis.
  • TCF21 influences cell cycle progression and autophagy.
  • TCF21 exhibits diverse functions in multiple human cancers.

Conclusions:

  • TCF21 is a significant factor in cancer development and progression.
  • Understanding TCF21's molecular basis offers new therapeutic avenues.
  • Further research into TCF21's multifaceted roles is warranted.
Keywords:
DNA methylationEMTTCF21cancercell cycleinvasionmetastasis

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