Related Experiment Video
Updated: Jul 31, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex
Ting Liu1, Yi-An Wang1, Qing Zang1
1School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Abstract:
A Cu(II) complex [Cu(bipy)(H2O)2(SO4)] (bipy = 2,2'-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. The binding modes between the complex and hsDNA were the electrostatic and embedded modes.
Related Concept Videos
Coordination Number and Geometry
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...
Inhibitors of Bacterial DNA Synthesis
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
