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Neurocysticercosis in Children with Seizures: A Cross-Sectional Study
Murli Manohar Gupta1, Nagendra Chaudhary1,2, Santosh Pathak3
1Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, Nepal.
International Journal of Pediatrics
|June 29, 2018
Summary
Neurocysticercosis (NCC) significantly increases seizure prevalence in Nepalese children. Older children and those with focal seizures showed higher NCC rates, indicating a need for targeted interventions.
Area of Science:
- Neurology
- Infectious Diseases
- Pediatrics
Background:
- Neurocysticercosis (NCC) is a major cause of pediatric seizures in low and middle-income countries (LMICs).
- Limited data exists on NCC prevalence and clinical features in children with seizures in South-Western Nepal.
Purpose of the Study:
- To determine the prevalence of NCC among children presenting with seizures.
- To describe the clinical characteristics of NCC in this pediatric population.
Main Methods:
- A study was conducted on children admitted with seizures between 2014-2016 at a tertiary hospital in Nepal.
- Neuroimaging (CT/MRI) was used to diagnose NCC.
- Logistic regression analyzed associations between NCC and patient characteristics/symptoms.
Main Results:
- Of 4962 children, 168 had seizures; 43% were diagnosed with NCC via CT scan.
- NCC prevalence increased significantly with age, highest in 13-16 year olds (57.1%).
- Children with NCC had a nearly 3-fold higher risk of seizure recurrence within 3 months of AED treatment.
Conclusions:
- NCC is a significant contributor to the burden of seizures in children in South-Western Nepal.
- The findings highlight the importance of considering NCC in the differential diagnosis of pediatric seizures in the region.
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