Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors

The synthesis of a few derivatives of the angiotensin converting enzyme inhibitor enalapril is described. In these molecules the chelating carbethoxy group is substituted with an imidazolyl one. The compounds were tested both in vitro and in vivo. None of them showed in vivo activity but only a marginal in vitro inhibitory activity.