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Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease
Zachary Junga1, Brett Theeler2, Manish Singla1
1Gastroenterology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD.
Abstract:
Infliximab is an anti-tumor necrosis factor α (TNFα) monoclonal antibody that treats moderate-to-severe Crohn's disease. In rare cases, infliximab has been associated with drug-induced aseptic meningitis. We present a 46-year-old woman with migraines and inflammatory Crohn's colitis treated with intravenous infliximab and methotrexate. She developed nuchal rigidity, photophobia, and headache 2 days after each of her infliximab infusions, with symptom resolution 1 week post-infusion. Her exam, imaging, and cerebrospinal fluid analysis were consistent with drug-induced aseptic meningitis. She discontinued infliximab and started vedolizumab with continued remission of her Crohn's disease.
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