Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

43.7K
Overview
43.7K
Overview of DNA Repair02:25

Overview of DNA Repair

33.8K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.8K
Base Excision Repair01:54

Base Excision Repair

26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.4K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.9K
Overview
40.9K
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

437
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
437
Abdominal Aorta01:25

Abdominal Aorta

2.4K
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VENUM (Vascular Education iN Undergraduate Medicine): a multicentre evaluation of undergraduate vascular education in the UK.

Annals of the Royal College of Surgeons of England·2023
Same author

Future of surgical registries.

The British journal of surgery·2021
Same author

Factors associated with delays in revascularization in patients with chronic limb-threatening ischaemia: population-based cohort study.

The British journal of surgery·2021
Same author

Willingness of patients to attend abdominal aortic aneurysm surveillance: The implications of COVID-19 on restarting the National Abdominal Aortic Aneurysm Screening Programme.

The British journal of surgery·2020
Same author

NICE Abdominal Aortic Aneurysm Guidelines Finally Published: How Will They Influence Aortic Practice in the UK and Beyond?

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2020
Same author

Comment on: Endovascular treatment of abdominal aortic aneurysm: a NICE U-turn.

The British journal of surgery·2020
Same journal

Outcomes reported in studies of anal high-grade squamous intraepithelial lesions treatments: systematic review.

BJS open·2026
Same journal

Mesh-fixation combinations and chronic postoperative inguinal pain after laparoscopic groin hernia repair: nationwide cohort study.

BJS open·2026
Same journal

Single-stapling versus double-stapling technique for rectal anastomosis-meta-analysis.

BJS open·2026
Same journal

Development of a predictive model for postoperative body mass index and diabetes outcomes after metabolic bariatric surgery: retrospective cohort study.

BJS open·2026
Same journal

Pattern of lymph node spread in gastric cancer: Western multicenter retrospective study.

BJS open·2026
Same journal

Effectiveness of perioperative calcium and vitamin D supplementation in preventing post-thyroidectomy hypocalcaemia: network meta-analysis of randomized trials.

BJS open·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
11:13

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

9.8K

Weekend effect in non-elective abdominal aortic aneurysm repair.

G K Ambler1,2, N B G Mariam3, U Sadat3

  • 1Division of Population Medicine Cardiff University Cardiff UK.

BJS Open
|June 29, 2018
PubMed
Summary
This summary is machine-generated.

The weekend effect on patient outcomes is not significant for acute abdominal aortic aneurysm (AAA) repair when confounding factors and coding are corrected. This study found no evidence of a weekend effect in UK patients undergoing non-elective AAA surgery.

More Related Videos

A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

14.8K
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

Published on: July 23, 2009

25.3K

Related Experiment Videos

Last Updated: Feb 8, 2026

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
11:13

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

9.8K
A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

14.8K
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

Published on: July 23, 2009

25.3K

Area of Science:

  • Vascular Surgery
  • Health Services Research
  • Patient Outcomes

Background:

  • The 'weekend effect' suggests worse patient outcomes for weekend admissions, influencing UK health policy.
  • Recent evidence questions the weekend effect, citing confounding factors and coding inaccuracies.
  • This study investigates these factors in patients with acute abdominal aortic aneurysm (AAA).

Purpose of the Study:

  • To investigate the 'weekend effect' in patients undergoing non-elective acute abdominal aortic aneurysm (AAA) repair.
  • To determine if confounding factors and coding issues explain apparent outcome disparities.
  • To assess the impact of weekend admission on in-hospital mortality and morbidity for AAA patients.

Main Methods:

  • A case-control study analyzed UK National Vascular Registry data (Jan 2013-Dec 2015) for non-elective AAA repair.
  • Patients were categorized into weekday and weekend treatment groups.
  • Outcomes (mortality, length of stay, complications) were compared after correcting for confounders and coding variations, particularly for ruptured AAA.

Main Results:

  • Initially, weekend admissions showed higher mortality (OR 1.69) and longer hospital stays (OR 1.21).
  • After correcting for confounding factors and coding issues, the weekend effect disappeared for mortality (corrected OR 1.09) and length of stay (corrected OR 1.06) in ruptured AAA cases.
  • Similar findings were observed for other morbidity outcomes, indicating no significant weekend disparity.

Conclusions:

  • There is no statistically significant 'weekend effect' in the treatment of non-elective acute abdominal aortic aneurysm (AAA) in the UK.
  • Apparent outcome differences are attributable to inadequate correction for confounding variables and coding inaccuracies.
  • Findings challenge the basis for health policy changes solely attributed to a weekend admission penalty.