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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Published on: June 16, 2014

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Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the

Kosaku Nitta1, Satoshi Iimuro2, Enyu Imai3

  • 1Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, 162-8666, Japan. knitta@twmu.ac.jp.

Clinical and Experimental Nephrology
|June 29, 2018
PubMed

Insights

Left ventricular hypertrophy (LVH) affects 23.4% of chronic kidney disease (CKD) patients. Independent risk factors include prior cardiovascular disease, higher BMI, systolic blood pressure, urinary albumin, and lower serum total cholesterol.

Area of Science:

  • Nephrology
  • Cardiology
  • Biostatistics

Background:

  • Left ventricular hypertrophy (LVH) is a known cardiovascular event predictor in chronic kidney disease (CKD).
  • The prevalence and risk factors of LVH in pre-dialysis CKD stages (3-5) require further examination.
  • Understanding LVH in CKD is crucial for cardiovascular risk stratification.

Purpose of the Study:

  • To investigate the prevalence of LVH in patients with stage 3-5 CKD.
  • To identify factors associated with increased left ventricular mass index (LVMI) in this cohort.
  • To establish a baseline for future longitudinal studies on LVH prognosis in CKD.

Main Methods:

  • Cross-sectional analysis of 1088 participants from the Chronic Kidney Disease Japan Cohort (CKD-JAC) study.
  • Measurement of left ventricular mass index (LVMI) using echocardiography.
  • Multivariate logistic regression to identify independent risk factors for LVH.

Main Results:

  • LVH was detected in 23.4% of the CKD cohort.
  • Independent risk factors for LVH included: past cardiovascular disease (OR 2.364), higher body mass index (OR 1.108), elevated systolic blood pressure (OR 1.173), increased urinary albumin (OR 1.425), and lower serum total cholesterol (OR 0.994).
  • Diabetes mellitus was the most common underlying disease (41.7%).

Conclusions:

  • Baseline data from the CKD-JAC study highlight significant associations between LVH and various risk factors in patients with reduced kidney function.
  • These findings underscore the importance of managing traditional cardiovascular risk factors in CKD patients.
  • Longitudinal studies are warranted to confirm the prognostic implications of LVH in CKD.
Abstract

Keywords:
AlbuminuriaAntihypertensive agentBody mass indexChronic kidney diseaseHypertensionLeft ventricular hypertrophyMineral metabolism

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