Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heat and Free Expansion01:24

Heat and Free Expansion

2.9K
The work done by a thermodynamic system depends not only on the initial and final states but also on the intermediate states—that is, on the path. Like work, when heat is added to a thermodynamic system, it undergoes a change of state, and the state attained depends on the path from the initial state to the final state. Consider an ideal gas cylinder fitted with a piston. When the cylinder is heated at a constant temperature, the gas molecules absorb energy and expand slowly in a...
2.9K
Thermal Expansion01:22

Thermal Expansion

5.7K
The expansion of alcohol in a thermometer is one of many commonly encountered examples of thermal expansion, which is the change in size or volume of a given system as its temperature changes. The most visible example is the expansion of hot air. When air is heated, it expands and becomes less dense than the surrounding air, which then exerts an upward force on the hot air to, for example, make steam and smoke rise, and hot air balloons float. The same behavior happens in all liquids and gases,...
5.7K
Binomial Expansion Using Pascal's Triangle01:30

Binomial Expansion Using Pascal's Triangle

268
Expanding a binomial expression such as (a + b)n results in a predictable sequence of terms that can be systematically derived using Pascal’s Triangle. This triangular array of numbers plays a central role in understanding and computing the coefficients of binomial expansions.Pascal’s Triangle is constructed such that each row corresponds to the coefficients of a binomial raised to a power. The topmost row, known as the zeroth row, corresponds to (a + b)0, and each successive row...
268
Expansion and Contraction in Masonry Walls01:19

Expansion and Contraction in Masonry Walls

1.4K
Masonry walls are subject to slight expansion and contraction due to variations in temperature and moisture. Thermal movement in masonry is relatively straightforward to measure and plan for. On the other hand, moisture movement poses more of a challenge. New clay masonry units typically absorb water and expand over time under normal environmental conditions. Conversely, new concrete masonry units tend to shrink as they lose the excess moisture acquired during their production process.
To...
1.4K
Thermal expansion and Thermal stress: Problem Solving01:27

Thermal expansion and Thermal stress: Problem Solving

2.2K
San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
2.2K
Inverse z-Transform by Partial Fraction Expansion01:20

Inverse z-Transform by Partial Fraction Expansion

716
The inverse z-transform is a crucial technique for converting a function from its z-domain representation back to the time domain. One effective method for finding the inverse z-transform is the Partial Fraction Method, which involves decomposing a function into simpler fractions with distinct coefficients. These fractions correspond to known z-transform pairs, facilitating the inverse transformation process.
To begin the process, the poles of the function are identified and the function is...
716

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood extracellular vesicles contribute to the exercise-mediated suppression of brain Aβ pathology in the App<sup>NL-G-F</sup> knockin mouse model of Alzheimer's disease.

Neurochemistry international·2026
Same author

Disease-modifying effect, safety and optimal dose of oral semaglutide tablets for patients with Parkinson's disease (MOST-ABLE study): protocol for a randomised, double-blind, placebo-controlled study.

BMJ open·2025
Same author

Mesenchymal stromal cells preserve alveolar macrophages by inducing Sesn2 expression via lactic acid production in a mouse model of bleomycin-induced lung injury.

Cell transplantation·2025
Same author

Oral administration of arginine suppresses Aβ pathology in animal models of Alzheimer's disease.

Neurochemistry international·2025
Same author

Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.

Disease models & mechanisms·2025
Same author

Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.

Nucleic acids research·2025

Related Experiment Video

Updated: Feb 8, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

13.7K

Repeat Expansion Disease Models.

Morio Ueyama1, Yoshitaka Nagai2

  • 1Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.

Advances in Experimental Medicine and Biology
|June 29, 2018
PubMed
Summary

Repeat expansion disorders are inherited neuromuscular diseases caused by gene mutations. Drosophila models aid in understanding these conditions and developing treatments for polyglutamine and noncoding repeat expansion diseases.

Keywords:
Amyotrophic lateral sclerosisDrosophilaNeurodegenerative diseasesNoncoding repeat expansion diseasesPolyglutamine diseasesRNA fociRepeat expansion diseasesRepeat-associated non-ATG translationSpinocerebellar ataxia

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.6K
Author Spotlight: Development of a Novel Finite Element Analysis Model for Improved Orthognathic Surgical Techniques
07:16

Author Spotlight: Development of a Novel Finite Element Analysis Model for Improved Orthognathic Surgical Techniques

Published on: October 20, 2023

1.9K

Related Experiment Videos

Last Updated: Feb 8, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

13.7K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.6K
Author Spotlight: Development of a Novel Finite Element Analysis Model for Improved Orthognathic Surgical Techniques
07:16

Author Spotlight: Development of a Novel Finite Element Analysis Model for Improved Orthognathic Surgical Techniques

Published on: October 20, 2023

1.9K

Area of Science:

  • Genetics and Molecular Biology
  • Neuroscience
  • Disease Mechanisms

Background:

  • Repeat expansion disorders are inherited neuromuscular diseases.
  • Caused by expansion mutations in disease-causing genes.
  • Includes polyglutamine (polyQ) diseases and noncoding repeat expansion diseases.

Purpose of the Study:

  • To review the utility of Drosophila disease models.
  • To elucidate molecular mechanisms of repeat expansion disorders.
  • To explore therapeutic development for these conditions.

Main Methods:

  • Utilizing established Drosophila models for repeat expansion disorders.
  • Investigating molecular pathways affected by repeat expansions.
  • Analyzing the impact of mutant proteins and aberrant RNA.

Main Results:

  • Drosophila models have been successfully established for both coding (polyQ) and noncoding repeat expansion diseases.
  • These models have significantly advanced the understanding of disease pathogenesis.
  • Insights gained are crucial for developing targeted therapies.

Conclusions:

  • Drosophila models are invaluable tools for studying repeat expansion disorders.
  • Further research using these models will accelerate therapeutic breakthroughs.
  • Understanding mechanisms is key to treating these complex neuromuscular diseases.