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The Influence of LPS-Induced Maternal Inflammation on Postnatal Collagen-Induced Arthritis

Atsuko Imai1, Eka Fujimoto1, Kazuto Sato2

  • 1Division of Clinical Nutrition, Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo, 112-8681, Japan.

Inflammation
|June 29, 2018
PubMed

Insights

Maternal inflammation, induced by lipopolysaccharide (LPS), delayed the onset of collagen-induced arthritis (CIA) in offspring mice. However, later analysis revealed increased interleukin-6 (IL-6) and decreased leptin, suggesting worsening arthritis pathophysiology.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Rheumatology
  • Perinatal Medicine

Background:

  • Maternal health and nutrition significantly impact offspring's long-term health and disease susceptibility.
  • The specific effects of maternal inflammation on offspring's immune and inflammatory responses remain incompletely understood.
  • Maternal inflammation's role in modulating offspring's immune and metabolic functions requires further investigation.

Purpose of the Study:

  • To investigate the impact of maternal inflammation on the development of collagen-induced arthritis (CIA) in offspring.
  • To analyze immunological and metabolic changes in offspring exposed to maternal inflammation.
  • To understand how maternal inflammation influences the pathophysiology of inflammatory diseases like rheumatoid arthritis.

Main Methods:

  • Female DBA/1J mice were injected with lipopolysaccharide (LPS) before conception to induce maternal inflammation.
  • Male offspring from LPS-treated dams (maternal LPS group, MLG) were used to study collagen-induced arthritis (CIA).
  • CIA was induced via collagen type II (CII) injections, and offspring were analyzed at 26 weeks for immunological and metabolic parameters.

Main Results:

  • Offspring from the MLG exhibited reduced joint swelling and lower severity scores in the early stages of CIA.
  • Histological analysis showed decreased joint destruction and lower CII-specific IgG titers in the MLG.
  • At 26 weeks, MLG offspring had significantly higher serum interleukin-6 (IL-6) levels and lower serum leptin levels, with a negative correlation between leptin and IL-6.

Conclusions:

  • Maternal inflammation does not simply suppress inflammation but may delay the onset of CIA in offspring.
  • Elevated IL-6 and reduced leptin at later stages suggest a potential worsening of arthritis pathophysiology.
  • Maternal inflammation can modulate the patterns of postnatal inflammatory responses in offspring.

Keywords:
collagen-induced arthritisleptinlipopolysaccharidematernal inflammationobesityrheumatoid arthritis

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