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Updated: Feb 8, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution
Ali Asghar Mohammadi1, Salman Taheri2, Arman Amini2
1Chemistry Department, Faculty of Sciences, Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 186-14335, Tehran, Iran. aliamohammadi@ccerci.ac.ir.
Abstract:
Triamide derivatives have been synthesized in good yields in a novel, one-pot, five-component, and efficient process by the reaction of Z-oxazolone, water, primary amines, aldehydes, isocyanides, in the presence of catalytic amount of KAl(SO4)2·12H2O (alum) as a non-toxic, reusable, inexpensive, and easily available reagent via Ugi reaction in aqueous solution.
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