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Updated: Feb 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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The microRNA signatures: aberrantly expressed miRNAs in prostate cancer

N Sharma1, M M Baruah2

  • 1Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Lavale, Mulshi, Pune, 412115, India. neetimohan27@gmail.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|June 29, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in prostate cancer. This review highlights consistently dysregulated miRNAs, like miRNA-141, as potential non-invasive biomarkers for diagnosis and therapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are regulatory non-coding oligonucleotides.
  • miRNA dysregulation is common in prostate cancer, influencing disease progression.
  • miRNAs show potential as cancer-specific biomarkers.

Purpose of the Study:

  • To review consistently reported dysregulated miRNAs in prostate cancer.
  • To discuss the role of these miRNAs in prostate cancer hallmarks.
  • To identify potential non-invasive biomarkers for prostate cancer diagnosis and therapy.

Main Methods:

  • Literature review of existing research on miRNA expression in prostate cancer.
  • Analysis of consistently reported dysregulated miRNAs.
  • Discussion of the regulatory roles of identified miRNAs in prostate cancer pathways.

Main Results:

  • Identified four consistently dysregulated miRNAs in prostate cancer: miRNA-141, miRNA-375, miRNA-221, and miRNA-21.
  • These miRNAs play roles in regulating key prostate cancer hallmarks.
  • Existing data shows inconsistencies, necessitating further validation.

Conclusions:

  • miRNA-141, miRNA-375, miRNA-221, and miRNA-21 are promising candidates for prostate cancer biomarkers.
  • Further validation is required to confirm their regulatory potential in prostate cancer management.
  • Consistent miRNA profiling could lead to improved diagnostic and therapeutic strategies.
Keywords:
BiomarkerMicroRNAProfilingProstate cancer

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