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Updated: Feb 8, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
Evidence for the Validity of the Psychopharmacotherapy-Structured Clinical Observation Tool: Results of a Factor and
John Q Young1, Rehana Rasul2, Patricia S O'Sullivan3
1Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Jyoung9@northwell.edu.
Objective:
The Psychopharmacotherapy-Structured Clinical Observation (P-SCO) is a direct observation tool designed to assess resident performance of a medication visit. This study examines two dimensions of validity for the P-SCO: internal structure and how scores correlate with another variable associated with competence (experience).
Methods:
The faculty completed 601 P-SCOs over 4 years. Multilevel exploratory factor analysis was performed with minimum thresholds for eigenvalue (≥ 1.0) and proportion of variance explained (≥ 5.0%). Internal reliability was assessed with Cronbach alpha. To examine how scores changed with experience, mean ratings (1-4 scale) were calculated for each factor by quarter of the academic year. Separate linear mixed models were also performed.
Results:
The analysis yielded three factors that explained 50% of the variance and demonstrated high internal reliability: affective tasks (alpha = 0.90), cognitive tasks (alpha = 0.84), and hard tasks (alpha = 0.74). Items within "hard tasks" were assessment of substance use, violence risk, and adherence, and inquiry about interactions with other providers. Monitoring adverse effects did not load on the hard task factor but also had overall low mean ratings. Compared to the first quarter, fourth quarter scores for affective tasks (b = 0.54, p < 0.01) and hard tasks (b = 0.46, p = 0.02) were significantly improved while cognitive tasks had a non-significant increase. For the hard tasks, the proportion of residents with a low mean rating improved but was still over 30% during the fourth quarter.
Conclusions:
The results provide evidence for the validity of the P-SCO with respect to its internal structure and how scores correlate with experience. Curricular implications are explored, especially for the tasks that were hard to learn.
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