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Related Experiment Video

Updated: Feb 8, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

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Published on: April 26, 2015

Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science.

Yifeng Peng^1,2, John N Kheir^1,2, Brian D Polizzotti^1,2

¹Translational Research Laboratory, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|June 29, 2018

Summary

Intravenous oxygen carriers like perfluorocarbon-emulsions and microbubbles show promise for treating hypoxia. Research focuses on improving their safety, stability, and efficacy for conditions such as cardiac arrest.

Keywords:

blood substitutes cardiac arrest intravascular oxygen delivery microbubbles polymeric biomaterials

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Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis

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Published on: March 29, 2016

Area of Science:

Biomedical Engineering
Cardiovascular Research
Emergency Medicine

Background:

Hypoxic conditions require effective oxygen delivery solutions.
Previous intravenous oxygen carriers (blood substitutes, microbubbles) had limited success.
Perfluorocarbon-emulsions and microbubbles are current candidates for oxygen carriers.

Purpose of the Study:

To review progress in perfluorocarbon-emulsions and microbubbles as intravenous gas carriers.
To discuss challenges including stability, safety, and efficacy.
To explore their potential in treating cardiac arrest.

Main Methods:

Literature review of previous and recent advancements.
Analysis of perfluorocarbon-emulsions and microbubbles.
Discussion of in vivo safety and oxygen transport.

Main Results:

Perfluorocarbon-emulsions and microbubbles are actively researched intravenous gas carriers.
Concerns remain regarding long-term stability and in vivo safety profiles.
Oxygen transport efficacy requires further optimization.

Conclusions:

Perfluorocarbon-emulsions and microbubbles represent promising avenues for intravascular oxygen delivery.
Further research is needed to address safety, stability, and efficacy concerns.
These carriers show potential as resuscitative therapeutics for cardiac arrest.