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Conducting a three-phase short circuit test on an unloaded synchronous machine helps understand its impact on the system. The AC fault current's oscillogram, with the DC offset removed, reveals that the waveform amplitude decreases from an initially high value to a steady-state level for one phase of the machine.
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

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Short Antimicrobial Peptides.

Komal Sharma1, Shams Aaghaz1, Kitika Shenmar1

  • 1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160062, India.

Recent Patents on Anti-Infective Drug Discovery
|June 29, 2018
PubMed
Summary
This summary is machine-generated.

Short antimicrobial peptides (SAMPs) offer a promising alternative to conventional antibiotics, exhibiting high efficacy against resistant microbes. Modifications enhance their stability and therapeutic potential, combating the global threat of antimicrobial resistance.

Keywords:
Peptidesantibioticsantimicrobial peptidesbacterial infectionsdrug resistancesungal infections.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Drug Discovery

Background:

  • Antibiotic resistance is a significant global health threat, driven by drug use and mutations.
  • Conventional antibiotics face increasing resistance, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To explore short antimicrobial peptides (SAMPs) as a viable alternative to conventional antibiotics.
  • To highlight the advantages of SAMPs, including broad-spectrum activity and resistance insusceptibility.

Main Methods:

  • Review of existing literature on SAMPs and peptidomimetics.
  • Discussion of structural modifications to enhance peptide stability and efficacy.
  • Analysis of SAMPs' mechanism of action, focusing on hydrophobicity and cationicity.

Main Results:

  • SAMPs demonstrate high activity against both drug-sensitive and drug-resistant microbes.
  • Modifications such as incorporating unnatural amino acids or protecting termini improve peptide stability.
  • SAMPs exhibit selective microbial cell lysis with reduced host cell toxicity.

Conclusions:

  • SAMPs, ranging from dipeptides to decapeptides, show significant antimicrobial potential.
  • Advancements in SAMP research are progressing from in vitro studies to clinical trials.
  • Peptide-based therapeutics, including SAMPs, offer renewed hope for combating antimicrobial resistance.