Related Experiment Video

Updated: Feb 8, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.7K

Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma

Yaoshu Teng1,2, Yuandong Li2, Zhihong Lin3

  • 1Department of Otorhinolaryngology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, PR China.

Epigenomics
|June 29, 2018
PubMed
Abstract

Insights

MicroRNA-214-3p is significantly decreased in sinonasal inverted papilloma (SNIP), suggesting its potential as a diagnostic biomarker and therapeutic target for SNIP.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Sinonasal inverted papilloma (SNIP) is a benign but locally aggressive tumor.
  • MicroRNAs (miRNAs) play crucial roles in tumorigenesis and cancer progression.
  • Understanding miRNA expression in SNIP is vital for diagnosis and treatment.

Purpose of the Study:

  • To investigate the expression profile of miRNAs in SNIP.
  • To determine the diagnostic and clinicopathological significance of miRNAs in SNIP.
  • To identify potential miRNA biomarkers for SNIP.

Main Methods:

  • miRNA microarray analysis to profile miRNA expression in SNIP tissues.
  • Bioinformatic and statistical analyses to assess miRNA functions and clinical relevance.
  • Quantitative real-time PCR to validate miRNA expression levels.

Main Results:

  • 37 miRNAs were upregulated and 21 were downregulated in SNIP.
  • Candidate miRNAs targeted genes involved in tumorigenesis pathways.
  • MiR-214-3p expression was significantly decreased in SNIP and correlated with staging and recurrence (AUC=0.932).

Conclusions:

  • MiR-214-3p shows potential as a diagnostic biomarker for SNIP.
  • MiR-214-3p may serve as a therapeutic target for SNIP management.
Keywords:
Human papilloma virusbioinformaticsbiomarkerinverted papillomamicroRNAmicroarraypathogenesispathwaysinonasal tumorstarget genes

More Related Videos

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.3K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

Related Concept Videos

Inverting and Non-inverting OpAmps01:20

Inverting and Non-inverting OpAmps

In an inverting amplifier, the input voltage is connected through a resistor to the inverting terminal. Meanwhile, the non-inverting terminal is grounded and a feedback resistor is established between the inverting and output terminal, as depicted in Figure 1.
1.8K
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.9K
Identifying Statistically Significant Differences: The F-Test01:14

Identifying Statistically Significant Differences: The F-Test

The F-test is used to compare two sample variances to each other or compare the sample variance to the population variance. It is used to decide whether an indeterminate error can explain the difference in their values. The underlying assumptions that allow the use of the F-test include the data set or sets are normally distributed, and the data sets are independent of each other. The test statistic F is calculated by dividing one variance by another. In other words, the square of one standard...
3.9K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
900
Taping Over Different Ground Profiles01:12

Taping Over Different Ground Profiles

Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...
398