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The detection of abscesses with diffusible tracers
International Journal of Nuclear Medicine and Biology
|January 1, 1985
Summary
Scintigraphy using 99mTc-DTPA effectively detects suspected inflammatory lesions and locates pus collections. This imaging technique reveals abscess characteristics like hyperemia and edema, aiding in diagnosis.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Pathophysiology
Background:
- Abscesses present diagnostic challenges in suspected infections.
- Understanding the pathophysiologic features of abscesses is crucial for diagnosis.
Purpose of the Study:
- To evaluate the utility of scintigraphy with diffusible tracers for detecting and localizing abscesses.
- To quantitatively study the pathophysiologic changes associated with inflammatory lesions.
Main Methods:
- Scintigraphy with 99mTc-DTPA was performed in six patients with suspected infections.
- An animal model was developed to quantitatively assess inflammatory lesions and pus volumes.
Main Results:
- Scintigraphy successfully outlined abscess margins and central portions in patients.
- Animal models showed increased blood volume, blood flow, and extracellular fluid in inflammatory lesions.
- Slow central tracer diffusion correlated with the presence of pus.
Conclusions:
- Scintigraphy with 99mTc-DTPA is a valuable tool for detecting inflammatory lesions and localizing pus.
- Hyperemia and edema are key pathophysiologic features of abscesses detectable by this method.