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Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters
Canser Yilmaz Demir1, Nureddin Yuzkat1, Yavuz Ozsular1
1From the Department of Plastic, Reconstructive, and Aesthetic Surgery and the Department of Anesthesiology and Reanimation, Yuzuncu Yil University Faculty of Medicine.
Plastic and Reconstructive Surgery
|June 29, 2018
Summary
Platelet count, mean platelet volume, and neutrophil-to-lymphocyte ratio can help predict Fournier gangrene prognosis. Lower platelet counts and higher neutrophil-to-lymphocyte ratios indicate a worse outcome.
Area of Science:
- Medical Science
- Clinical Medicine
- Surgical Pathology
Background:
- Fournier gangrene is a severe necrotizing infection of the perineum and genitalia.
- Early diagnosis and prognostic assessment are crucial for effective management.
Purpose of the Study:
- To investigate the association between hematological parameters and Fournier gangrene prognosis.
- To identify potential biomarkers for predicting disease severity and mortality.
Main Methods:
- Retrospective analysis of 74 hospitalized Fournier gangrene patients.
- Evaluation of mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet count (PLT).
- Correlation and ROC curve analyses to determine prognostic values.
Main Results:
- Non-survivors had significantly higher NLR and MPV, and lower PLT compared to survivors.
- Mortality correlated negatively with PLT and positively with NLR and MPV.
- Defined cutoff values for PLT, NLR, and MPV for prognostic assessment.
Conclusions:
- PLT, MPV, and NLR are potential prognostic markers for Fournier gangrene.
- Established threshold values can aid in patient monitoring and risk stratification.
- Further prospective studies are needed to confirm the role of these parameters.
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