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Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis

Zhen Zhang1, Junke Ou, Peiling Cai

  • 1School of Medicine, Chengdu University, Chengdu, China.

Medicine
|June 29, 2018
PubMed

Insights

The PON1 Q192R polymorphism shows a weak association with coronary heart disease (CHD) risk in the Chinese population. This meta-analysis clarifies previous discrepancies regarding this genetic link.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Population Genetics

Background:

  • The link between the PON1 Q192R polymorphism and coronary heart disease (CHD) has been inconsistently reported.
  • Previous studies show discrepancies, necessitating further investigation.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between the PON1 Q192R polymorphism and CHD risk.
  • To clarify the inconsistent findings in the Chinese population.

Main Methods:

  • A comprehensive literature search was performed across PubMed, EMBASE, and China National Knowledge Infrastructure databases.
  • Included case-control studies were independently selected by two reviewers.
  • Data were analyzed using STATA software (v12.0).

Main Results:

  • Thirteen studies with 4353 cases and 4882 controls were included.
  • A statistically significant association was found under the recessive genetic model (R/R vs Q/R + Q/Q, OR=1.111, 95% CI=1.017-1.214).
  • No significant associations were observed under the allele, homozygous, or dominant genetic models.

Conclusions:

  • The PON1 Q192R polymorphism exhibits a weak association with CHD risk in the Chinese population.
  • This meta-analysis provides a clearer understanding of the genetic association in this demographic.
Abstract

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