Related Experiment Video
Updated: Feb 8, 2026

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells
Published on: November 4, 2022
Impaired retinal pigment epithelium in paclitaxel-induced macular edema: A case report
Chia-Hsin Shih1, Yuan-Chieh Lee
1Department of Ophthalmology, Buddhist Tzu Chi General Hospital Department of Ophthalmology and Visual Science Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Rationale:
Cystoid macular edema (CME) is a rare complication of the paclitaxel. However, the pathophysiology was unknown.
Patient Concerns:
A 60-year-old female presented with bilateral blurred vision due to cystoid macular edema after taking 12-course paclitaxel for her breast cancer. Optical coherence tomography (OCT), fluorescein angiography (FAG), indocyanine green angiography (ICGA), electroretinogram (ERG) and electrooculogram (EOG) were performed.
Diagnoses:
Paclitaxel-induced macular edema.
Interventions:
Paclitaxel was discontinued and supportive treatment with pentoxifylline was given.
Outcomes:
The OCT showed bilateral cystoid macular edema. Impaired filling of choriocapillaries was noted on the ICGA; while EOG revealed decreased Arden ratio. The visual acuity, cystoid macular edema and decreased Arden ratio improved slowly over six months.
Lessons:
Paclitaxel rarely causes cystoid macular edema. The damage of choriocapillaries and retinal pigment epithelium might be the underlying cause. Immediate discontinuation of the drug helps visual recovery.
Related Concept Videos
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Data Reporting and Recording
Types of Reports I: Hands-off Report
Following are the key components and categories of hand-off reports:
Purpose and Process:
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Induced Pluripotent Stem Cells

