Related Experiment Video
Updated: Feb 8, 2026

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
Published on: February 14, 2025
[Fatal renal and neurological complications after aortic arch repair in newborns]
Yu S Sinelnikov1, E N Gasanov2, I A Soynov3
1Sukhanov Federal Center for Cardiovascular Surgery of Healthcare Ministry of Russia, Perm, Russia.
Aim:
To evaluate effectiveness and safety of various methods of cerebral and visceral protection during aortic arch surgery in infants.
Material And Methods:
Retrospective analysis included 60 patients after aortic arch repair followed by different cerebral protection technique who have been assessed for neurological status and visceral injury in early and long-term postoperative period. Aortic arch surgery with deep hypothermic circulatory arrest for congenital diseases was performed in 26 patients (group 1) and antegrade unilateral selective cerebral perfusion in 34 patients (group 2).
Results:
Cerebral complications occurred in 28.5% of patients of the 1st group and in 7.9% of patients of the 2nd group.
Conclusion:
Odds ratio for neurological event is significantly lower in group 2: 0.17 (0.06-0.69; p=0.02). However, there were more patients with renal dysfunction in this group compared with group 1: 58.7% vs. 23.7% (p=0.02).
Related Concept Videos
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...
Mismatch Repair
Overview of DNA Repair
Chemically...
Base Excision Repair
The first step of...
Nucleotide Excision Repair
Hemodialysis II: Procedure and Complications

