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Updated: Feb 8, 2026

Determination of Total Lipid and Lipid Classes in Marine Samples
Published on: December 11, 2021
Total Synthesis of Salimabromide: A Tetracyclic Polyketide from a Marine Myxobacterium
Matthias Schmid1,2, Adriana S Grossmann1, Klaus Wurst3
1Department of Chemistry , Ludwig-Maximilians-University Munich , Butenandtstrasse 5-13 , 81377 Munich , Germany.
Abstract:
Salimabromide is an antibiotic polyketide that was previously isolated from the obligate marine myxobacterium Enhygromyxa salina, and its densely functionalized and conformationally rigid tetracyclic framework is unprecedented in nature. Herein we report the first chemical synthesis of the target structure by employing a series of well-orchestrated, robust transformations, highlighted by an acid-promoted, powerful Wagner-Meerwein rearrangement/Friedel-Crafts cyclization sequence to forge the two adjacent quaternary carbon centers embedded in the tetrahydronaphthalene. A high-yielding ketiminium mediated [2+2]-cycloaddition was also utilized for the simultaneous construction of the remaining three stereocenters.
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