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Laser Non-Contact Drug Delivery Methods: Mathematical and Experimental Substantiation
1Biomedical Technical Systems Department, Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia.
Critical Reviews in Biomedical Engineering
|June 29, 2018
Summary
Novel laser technologies offer new ways for transcutaneous drug delivery. Laser impregnation and injection show potential for enhancing drug diffusion through skin, with mathematical models and experimental results supporting clinical applications.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Laser Physics
Background:
- Parenteral drug delivery traditionally involves needles, posing risks like infection and pain.
- Limitations exist in current transdermal drug delivery methods for efficient molecule penetration.
- Laser technology presents a promising avenue for non-invasive or minimally invasive drug administration.
Purpose of the Study:
- To explore novel laser-based methods for transcutaneous drug delivery.
- To develop a mathematical model for optimizing laser impregnation parameters.
- To experimentally evaluate the efficacy of laser injection for various drug formulations.
Main Methods:
- Construction of a mathematical model to determine laser impregnator parameters (energy density, pulse duration, repetition frequency).
- Estimation of enhanced drug diffusion rates through multilayer structures using the model.
- Experimental investigation of Erbium: Yttrium Aluminum Garnet (Er:YAG) laser injection of spirit solutions, aqueous solutions, and ointments into gelatinous gel and autopsy skin samples.
Main Results:
- The mathematical model provides a method for calculating optimal laser parameters for impregnation.
- Laser impregnation is shown to potentially increase drug diffusion rates through skin.
- Experimental results demonstrate successful injection of diverse drug media via Er:YAG laser into various substrates.
Conclusions:
- Laser impregnation and laser injection are viable novel methods for transcutaneous drug delivery.
- The developed mathematical model aids in optimizing laser parameters for enhanced drug diffusion.
- These laser-based transcutaneous drug delivery methods hold potential for future clinical applications.
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