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Molecular Photoacoustic Contrast Agents: Design Principles & Applications
Raymond E Borg1, Jonathan Rochford1
1Department of Chemistry, University of Massachusetts Boston, Boston, MA.
Photochemistry and Photobiology
|June 29, 2018
Summary
Molecular photoacoustic contrast agents (MPACs) are revolutionizing deep-tissue biomedical imaging. This review surveys the latest advancements in MPAC design and applications for enhanced in vivo imaging.
Area of Science:
- Biomedical Imaging
- Nanotechnology
- Optical Physics
Background:
- Photoacoustic imaging (PAI) offers high resolution and contrast for deep-tissue visualization.
- PAI is nonionizing, noninvasive, and merges optical and ultrasound imaging capabilities.
- Exogenous contrast agents are crucial for advancing PAI sensitivity and specificity.
Purpose of the Study:
- To review the current state of molecular photoacoustic contrast agents (MPACs).
- To discuss the fundamental design principles of MPACs.
- To cover MPAC applications in biomedical imaging.
Main Methods:
- Literature review of prior and current reports on MPACs.
- Analysis of design principles for various MPAC materials.
- Survey of MPAC applications in biomedical imaging.
Main Results:
- Significant momentum in the development of diverse MPACs, from small molecules to nanoparticles.
- MPACs are being investigated for a wide range of biomedical imaging applications.
- Advancements in dye materials are expanding the complexity and utility of MPACs.
Conclusions:
- MPACs are critical for the advancement of in vivo photoacoustic imaging.
- Understanding MPAC design principles is key to optimizing their performance.
- The field of MPACs holds great promise for future biomedical imaging innovations.
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