Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

143
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
143
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.2K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.2K
Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

334
Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
For example, consider a student who struggles to understand their...
334
Coping Strategies: Emotion Focused01:20

Coping Strategies: Emotion Focused

339
Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
339
Horney's Sociocultural Approach01:27

Horney's Sociocultural Approach

973
Karen Horney's psychoanalytic theories emphasize the potential for self-realization and the importance of addressing social and cultural, rather than biological, factors in personality development. She challenged traditional Freudian views, particularly Freud's concept of "penis envy," which she argued stemmed from cultural influences rather than inherent biological differences. Horney believed that any sense of inferiority in women was a result of societal conditioning, such as...
973
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

440
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
440

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of Brain-Derived Estrogen Is Associated With Sex- and Age-Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression.

Aging cell·2026
Same author

Dorsal CA1 projections to nucleus accumbens and lateral septum differentially regulate social and locomotor behavior.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same author

Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice.

Scientific reports·2026
Same author

Association between fibrinogen and decline in cardiorespiratory fitness in patients undergoing cardiopulmonary exercise testing: a large cross-sectional study.

Frontiers in cardiovascular medicine·2026
Same author

Priming Effects on Soil Organic Matter Mineralization by Carbon Substrates: A Global Meta-Analysis.

Global change biology·2026
Same author

Empagliflozin preserves cardiac function and modulates metabolism in a mouse model of Duchenne muscular dystrophy.

bioRxiv : the preprint server for biology·2026
Same journal

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex.

Journal of neurochemistry·2026
Same journal

Splice Type-Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation.

Journal of neurochemistry·2026
Same journal

Neurobiological and Behavioral Consequences of Prenatal Methadone or Buprenorphine Exposure: Insight From Animal Models.

Journal of neurochemistry·2026
Same journal

Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell-Based Therapy.

Journal of neurochemistry·2026
Same journal

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis.

Journal of neurochemistry·2026
Same journal

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage.

Journal of neurochemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 22, 2025

Real-Time Dynamic Collection of Hippocampal Extracellular Fluid from Conscious Rats Using a Microdialysis System
05:43

Real-Time Dynamic Collection of Hippocampal Extracellular Fluid from Conscious Rats Using a Microdialysis System

Published on: October 21, 2022

2.9K

HCN channels in the hippocampus regulate active coping behavior.

Daniel W Fisher1, Ye Han1, Kyle A Lyman1

  • 1Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Journal of Neurochemistry
|June 29, 2018
PubMed
Summary
This summary is machine-generated.

Altering HCN channel function in the CA1 brain region promotes active coping behaviors. This research links neuronal excitability to adaptive stress responses, offering new insights into neuropsychiatric conditions.

Keywords:
HCN ChannelTRIP8bcopinghippocampusmice

More Related Videos

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
10:20

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

8.8K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.6K

Related Experiment Videos

Last Updated: Dec 22, 2025

Real-Time Dynamic Collection of Hippocampal Extracellular Fluid from Conscious Rats Using a Microdialysis System
05:43

Real-Time Dynamic Collection of Hippocampal Extracellular Fluid from Conscious Rats Using a Microdialysis System

Published on: October 21, 2022

2.9K
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
10:20

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

8.8K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.6K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Science

Background:

  • Active coping is crucial for managing stress and improving outcomes in various diseases.
  • Research on coping styles has primarily focused on neurotransmitters, with limited understanding of neuronal excitability in key brain regions.
  • HCN channels regulate neuronal excitability, and their current (Ih) in the CA1 area is altered by chronic stress.

Purpose of the Study:

  • To investigate the role of HCN channels in the CA1 region of the hippocampus in regulating active coping behaviors.
  • To determine if reducing HCN channel function in CA1 leads to increased active coping.

Main Methods:

  • Global knockout of TRIP8b, a protein essential for HCN channel function, was used to assess its impact on coping.
  • A viral strategy employing a dominant-negative TRIP8b isoform was utilized to specifically reduce HCN channel expression and Ih in CA1 pyramidal neurons.

Main Results:

  • Global loss of TRIP8b resulted in active coping behaviors across multiple assays.
  • Viral-mediated reduction of TRIP8b in CA1 led to decreased Ih and a significant increase in active coping.

Conclusions:

  • Changes in HCN channel function within the CA1 region directly influence an individual's coping style.
  • This study establishes a link between neuronal excitability regulated by HCN channels and adaptive stress responses.