Related Experiment Video

Updated: Feb 8, 2026

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
07:47

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

2.8K

Mir-1287 suppresses the proliferation, invasion, and migration in hepatocellular carcinoma by targeting PIK3R3

Junhao Lu1, Licheng Tang1, Yuqiang Xu2

  • 1State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

Journal of Cellular Biochemistry
|June 29, 2018
PubMed

Insights

MicroRNA-1287 (mir-1287) is suppressed in hepatocellular carcinoma (HCC). Upregulating mir-1287 inhibits HCC tumor growth by targeting PIK3R3, suggesting potential miRNA-based therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) regulate gene expression post-translationally.
  • Aberrant miRNA levels are observed in tumors, but their roles are unclear.
  • Hepatocellular carcinoma (HCC) is a significant global health concern.

Purpose of the Study:

  • To investigate the role of mir-1287 in hepatocellular carcinoma (HCC).
  • To identify molecular targets of mir-1287 in HCC.
  • To explore potential miRNA-based therapeutic strategies for HCC.

Main Methods:

  • Bioinformatic analysis of The Cancer Genome Atlas database.
  • Microarray-based comparison of miRNA expression in HCC cell lines.
  • In vitro functional assays to assess tumorigenesis phenotypes.
  • Direct targeting validation of PIK3R3 mRNA by mir-1287.

Main Results:

  • Mir-1287 levels are significantly suppressed in HCC cells.
  • Upregulation of mir-1287 reduces HCC cell tumorigenesis in vitro.
  • Mir-1287 directly targets and downregulates PIK3R3 mRNA.
  • PIK3R3 is identified as a tumor-promoting factor in HCC.

Conclusions:

  • Aberrant suppression of mir-1287 contributes to HCC development.
  • Mir-1287 acts as a tumor suppressor in HCC by targeting PIK3R3.
  • Mir-1287 represents a potential biomarker and therapeutic target for HCC.
Keywords:
PIK3R3cell proliferationhepatocellular carcinomamir-1287tumor metastasis

More Related Videos

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids07:25

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Published on: August 18, 2023

2.6K
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Migration00:53

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
8.9K
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.7K
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.8K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
710