Direct uterine sampling using the SAP-l sampler device to detect endometrial lesions during histopathological...

Area of Science:

• Gynecologic Oncology
• Pathology
• Minimally Invasive Procedures

Background:

• Endometrial biopsy is crucial for diagnosing uterine pathologies.
• Traditional methods like hysteroscopy and D&C can be invasive.
• There is a need for minimally invasive sampling techniques.

Purpose of the Study:

• To assess the endometrial SAP-l sampler's adequacy and accuracy in detecting endometrial lesions.
• To compare SAP-l sampling with histopathological findings.

Main Methods:

• 182 patients requiring endometrial biopsy were enrolled.
• Endometrial tissue was collected using the SAP-l sampler prior to hysteroscopy or D&C.
• Histopathological examination served as the gold standard.

Main Results:

• Adequate specimens were obtained in 81.32% of patients.
• SAP-l showed high sensitivity and specificity for endometrial carcinoma (82.35%) and atypical hyperplasia (37.5%).
• Diagnostic accuracy was limited for focal lesions, polyps (12.5% sensitivity), and submucosal leiomyomas.

Conclusions:

• The SAP-l sampler is a minimally invasive option for endometrial sampling.
• It is useful for detecting endometrial carcinoma and atypical hyperplasia, especially when not focal.
• It is not recommended for diagnosing endometrial polyps or submucosal leiomyomas.