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Updated: Feb 8, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells
Gang Huang1, Jinliang Yang1, Like Zhang1
1Department of Thoracic Surgery, The 3rdHospital of HeBei Medical University, NO.139, Zi Qiang Road, Shi Jia Zhuang, HeBei, 050051, China.
Background:
The anti-lung tumor potential of 11-carbonyl-β-boswellic acid was investigated.
Materials & Methods:
The inhibitory effects of 11-carbonyl-β-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation, apoptosis, cell cycle and molecular mechanisms in NSCLC H446 cells in vitro. The results showed that the growth of H446 cells was significantly inhibited by 11-carbonyl-β-boswellic acid in a dose- and time-dependent manner. Meanwhile, 11-carbonyl-β-boswellic acid induced cell apoptosis and cell cycle G2-M phase arrest in H446 cells.
Results:
Mechanistically, 11-carbonyl-β-boswellic acid could activate JNK signaling pathway, down-regulate the expression of surviving protein, and activate the cleavage of PARP, leading to marked inhibitory effect on H446 cells.
Conclusions:
These findings suggest that 11-carbonyl-β-boswellic acid may be a potential usefulness for preventing and treatment of NSCLC.
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