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Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button
Nathaniel S Woodling1, Linda Partridge2
1Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Neuron
|June 29, 2018
Abstract:
Parkinson's disease patients report sleep disturbances well ahead of motor symptoms. In this issue of Neuron, Valadas et al. (2018) report that the disease genes pink1 and parkin exert novel, cell-type-specific effects to modulate ER-mitochondria contacts, neuropeptidergic transmission, and sleep patterns.