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Updated: Feb 8, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Effective Desensitization to Tocilizumab in Delayed Hypersensitivity Reaction
Gabriele Cortellini1, Fabio Mascella1, Margherita Simoncelli1
1Internal Medicine, Allergy Unit, Rimini Hospital, Azienda sanitaria Romagna, Rimini, Italy.
Abstract:
We present tocilizumab desensitization of a 47-year-old woman affected by rheumatoid arthritis with full body delayed erythematous urticarial reaction. Skin test for tocilizumab gave cutaneous reaction after 6 h at 20 mg/mL. The schedule of desensitization was then adapted for non-immediate reaction. We prepared a desensitization procedure reaching the cumulative dose of 516 mg in 5 weeks. After 6 months, the repetition of skin tests had a negative result, with demonstration of tolerance induction. Today the patient has good control of the disease.
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