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Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative

Michael J Pishvaian1,2, Robert J Bender2, David Halverson2

  • 1Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C. pishvaim@georgetown.edu.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 30, 2018
PubMed

Insights

The Know Your Tumor program successfully implemented precision medicine for pancreatic cancer patients, identifying actionable genomic alterations in 50% of cases. Matched therapies significantly improved progression-free survival, supporting precision oncology

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Pancreatic cancer care lacks broad access to precision medicine.
  • The Know Your Tumor (KYT) program aimed to bridge this gap.
  • KYT utilized a turn-key system for multiomic profiling.

Purpose of the Study:

  • To implement a precision medicine system for pancreatic cancer.
  • To identify actionable molecular alterations for targeted therapies.
  • To assess the impact of precision medicine on patient outcomes.

Main Methods:

  • Collected tumor samples from 640 patients across 287 practices.
  • Performed multiomic profiling (genomic, proteomic, phosphoprotein) using accredited labs.
  • Utilized a tumor board to review molecular results and recommend treatments.

Main Results:

  • Tumor samples were adequate for analysis in over 90% of patients.
  • Actionable genomic alterations were found in 50% of patients, with 27% highly actionable.
  • Patients receiving matched therapy for highly actionable biomarkers showed significantly longer progression-free survival (4.1 vs. 1.9 months).

Conclusions:

  • A comprehensive precision medicine system is feasible in community and academic settings.
  • Over 25% of pancreatic cancers harbor highly actionable molecular findings.
  • Precision oncology, particularly matched therapy, significantly improves progression-free survival in pancreatic cancer.

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