Related Experiment Video

Updated: Feb 8, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

1.2K

Anti-PD-1 Therapy-Associated Perforating Colitis

Romulo Celli1, Harriet M Kluger2, Xuchen Zhang1

  • 1Department of Pathology, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.

Case Reports in Gastrointestinal Medicine
|June 30, 2018
PubMed

Insights

Immune checkpoint inhibitors like PD-1 blockers can cause colitis. This case highlights a rare instance of colonic perforation associated with PD-1 inhibitor treatment for advanced melanoma.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1), its ligand (PDL-1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) are established treatments for advanced cancers.
  • While immune-related adverse effects like colitis are known for these therapies, perforating colitis linked to anti-PD-1/PD-L1 agents is uncommon.

Observation:

  • A patient with metastatic melanoma developed colonic perforation.
  • This event occurred following recent treatment with pembrolizumab, a PD-1 inhibitor.

Findings:

  • This case represents a rare occurrence of perforating colitis associated with anti-PD-1/PD-L1 therapy.
  • The patient's condition was linked to pembrolizumab treatment for metastatic melanoma.

Implications:

  • Increased awareness of anti-PD-1/PD-L1-associated colitis and perforation is crucial.
  • Timely diagnosis and management are essential for patients receiving these increasingly utilized immunotherapies.

More Related Videos

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

1.2K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.7K

Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
619
PD Controller: Design01:26

PD Controller: Design

In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
659
Time-Domain Interpretation of PD Control01:07

Time-Domain Interpretation of PD Control

Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...
408
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
741
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Frequency-Domain Interpretation of PD Control01:24

Frequency-Domain Interpretation of PD Control

Proportional-Derivative (PD) controllers are widely used in fan control systems to improve stability and performance. A fan control system can be effectively represented using a Bode plot to illustrate the impact of a PD controller through its transfer function. The Bode plot visually conveys how PD control modifies the fan's response across various frequencies, providing a frequency domain interpretation of the controller's behavior.
The proportional control gain, combined with the...
392