Treatment-emergent hypomania possibly associated with over-the-counter supplements

Area of Science:

• Integrative Medicine
• Psychiatry
• Pharmacology

Background:

• Complementary and alternative medicine (CAM) use is increasing in Western countries.
• CAM therapies are often perceived as safer, less stigmatized, and more affordable.
• Limited scientific evidence exists for the safety and efficacy of many CAM treatments for depression.

Purpose of the Study:

• To report a case of hypomania induced by a combination of S-adenosylmethionine (SAMe) and 5-hydroxytryptophan (5-HTP).
• To highlight the potential risks associated with CAM use for depression.

Main Methods:

• Case report of a 42-year-old male patient treated for depression.
• Analysis of adverse events following initiation of SAMe and 5-HTP therapy.

Main Results:

• The patient developed hypomania approximately one week after starting SAMe and 5-HTP.
• This suggests a potential link between the combined supplement therapy and the onset of hypomanic symptoms.

Conclusions:

• The combination of SAMe and 5-HTP may precipitate hypomanic episodes in susceptible individuals.
• Further research is needed to establish the safety profile of SAMe and 5-HTP, especially in combination, for treating depression.