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Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace

Carmen M T Lageweg1, Mayke E van der Putten2, Johannes B van Goudoever3,4

  • 1Department of Pediatrics, Subdivision of Neonatology, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.

Bone Reports
|June 30, 2018
PubMed

Insights

Dual-energy X-ray absorptiometry (DXA) and phalangeal quantitative ultrasound (pQUS) show weak correlations and poor agreement for assessing bone health in former preterm children. DXA is not replaceable by pQUS in this population.

Area of Science:

  • Pediatrics
  • Bone Health
  • Medical Imaging

Background:

  • Preterm infants face increased risk of impaired bone health later in life.
  • Dual-energy X-ray absorptiometry (DXA) is the gold standard for bone mineralization assessment.
  • Phalangeal quantitative ultrasound (pQUS) offers a radiation-free, accessible alternative.

Purpose of the Study:

  • To compare the diagnostic equivalence of DXA and pQUS in former preterm children.
  • To determine if pQUS can reliably assess bone health in this specific cohort.

Main Methods:

  • Sixty former preterm children (9-10 years old) underwent both DXA and pQUS measurements.
  • DXA assessed bone mineral content and density; pQUS measured speed of sound and bone transit time.
  • Statistical analyses included correlation, partial correlation, Bland-Altman analysis, and cross-tabulation.

Main Results:

  • Weak, statistically significant correlations were found between DXA and pQUS (continuous and Z-scores).
  • Boys showed moderate correlations, while girls' correlations were not significant.
  • Bland-Altman analysis indicated poor agreement; sensitivity and specificity varied widely.

Conclusions:

  • DXA and pQUS demonstrate weak correlations and poor agreement in former preterm children.
  • pQUS is not equivalent to DXA and cannot replace it for bone health assessment in this group at 9-10 years of age.
Abstract

Keywords:
AD-SoS, amplitude dependent speed of soundBMC, bone mineral contentBMD, bone mineral densityBTT, bone transit timeBone developmentChildrenCorrelationDXA, dual-energy X-ray absorptiometry-scanDual-energy X-ray absorptiometry-scanISCD, International Society of Clinical DensitometryQUS, quantitative ultrasoundSOS, speed of soundSpeed of soundUltrasoundpQUS, phalangeal quantitative ultrasound

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