Related Experiment Video
Updated: Feb 8, 2026
08:24
Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
Published on: March 14, 2020
7.3K
Bone histomorphometry in the evaluation of osteomalacia
Arti Bhan1, Shijing Qiu2, Sudhaker D Rao2
1Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Henry Ford Health System, Detroit, MI, 48201, United States.
Bone Reports
|June 30, 2018
Summary
Bone histomorphometry, while underutilized in clinical practice, offers crucial insights beyond bone density scans. It aids in diagnosing metabolic bone disorders and understanding treatment effects.
Area of Science:
- Bone biology and metabolic bone diseases.
Background:
- Bone mineral density (BMD) is widely used for osteoporosis management.
- BMD measurements cannot differentiate between osteoporosis and other metabolic bone disorders.
- BMD lacks information on bone microarchitecture, cellular activity, and mineralization.
Purpose of the Study:
- To highlight the diagnostic and research value of bone histomorphometry.
- To emphasize its role in understanding metabolic bone diseases and treatment efficacy.
Main Methods:
- Review of the diagnostic capabilities of bone histomorphometry.
- Comparison of histomorphometry with bone mineral density measurements.
- Discussion of histomorphometry's contribution to bone biology research.
Main Results:
- Bone histomorphometry can distinguish various metabolic bone disorders beyond osteoporosis.
- It provides essential data on bone microarchitecture, cellular function, and mineralization.
- Histomorphometry has significantly advanced understanding of bone biology and therapeutic mechanisms.
Conclusions:
- Bone histomorphometry remains a vital research tool for specific diagnoses and evaluating treatment effects.
- Its detailed insights are essential for complex metabolic bone disease management.
- Despite limited clinical use, its research contributions are invaluable.
Related Concept Videos
01:55Bone Structure
51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
01:40Bone Remodeling
40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
01:27Compact Bone
16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
01:29Bone Disorders
5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
01:12The Hyoid Bone
5.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K
01:09Spongy Bone
8.0K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
8.0K