Stimulation of cyclic AMP production in chick renal tissue by cadmium and manganese

The effects of cadmium on production of cyclic AMP by partially purified chick renal plasma membrane preparations and binding of 125I-parathyrin to the membranes have been investigated. At certain concentrations Cd2+ ions (and Mn2+ ions) markedly stimulated the production of cyclic AMP by the tissue. It was found that concentrations of Cd2+ roughly in the same range were also capable of stimulating binding of 125I-parathyrin to the membrane preparations.