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Measuring Delay Discounting in Humans Using an Adjusting Amount Task
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5-HT3 antagonists decrease discounting rate without affecting sensitivity to reward magnitude in the delay

Marina Mori1, Iku Tsutsui-Kimura2,3,4, Masaru Mimura1

  • 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Psychopharmacology
|June 30, 2018
PubMed
Summary
This summary is machine-generated.

Researchers found that 5-HT3 antagonists reduce impulsive choice in mice by lowering delay discounting rates. This method for assessing impulsive choice is applicable to mouse models, advancing research on serotonin

Keywords:
Delay discounting taskExponential functionGranisetronImpulsive choiceOndansetronSerotonin

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Animal Models

Background:

  • Impulsive choice in rodents is often measured by %large choice in delay-discounting tasks (DDT).
  • %large choice is influenced by both reinforcer magnitude sensitivity and discounting rate, necessitating methods to differentiate these parameters.
  • The serotonin (5-HT) system's role in impulsive choice is known, but its specific effects on discounting rate via modulators are underexplored.

Purpose of the Study:

  • To perform a discounting parameter analysis in mice.
  • To examine the effects of various serotonin (5-HT) modulators on discounting rate in mice.

Main Methods:

  • Delay-discounting tasks (DDTs) with varying delay schedules were employed to determine optimal conditions for assessing delay-discounting rates in mice.
  • The impact of a 5-HT reuptake inhibitor (paroxetine), a 5-HT1A receptor agonist (8-OH-DPAT), and two 5-HT3 receptor antagonists (granisetron, ondansetron) on impulsive choice was investigated.

Main Results:

  • Mice exhibited typical delay discounting at shorter delay schedules (up to 4s).
  • Discounting rates were derived from %large choice data under shorter delay schedules using an exponential function.
  • 5-HT3 receptor antagonists (granisetron, ondansetron) significantly decreased discounting rates without altering sensitivity to reinforcer magnitude; paroxetine and 8-OH-DPAT had no significant effect.

Conclusions:

  • A method for calculating discounting rates, previously used in rats, is applicable to mouse models.
  • Evidence suggests that 5-HT3 receptor antagonism effectively modulates impulsive choice in mice by reducing the discounting rate.