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Sensory Functions of the Skin01:16

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Related Experiment Video

Updated: Feb 8, 2026

Measuring Neuromuscular Junction Functionality
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Sudomotor function testing by electrochemical skin conductance: does it really measure sudomotor function?

Sharika Rajan1, Marta Campagnolo1, Brian Callaghan1

  • 1Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Palmer 111, Boston, MA, USA.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|June 30, 2018
PubMed
Summary

Electrochemical skin conductance (ESC) testing, also known as Sudoscan, shows inconsistent results and lacks biological plausibility for diagnosing small fiber neuropathy. Most studies are manufacturer-funded, raising concerns about its reliability as a diagnostic tool.

Keywords:
Electrochemical skin conductancePeripheral autonomic functionSmall fiber neuropathySudoscan

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Diagnostic Technologies

Background:

  • Electrochemical skin conductance (ESC) is a non-invasive sweat function test.
  • It was developed as a potential diagnostic marker for small fiber neuropathy.

Purpose of the Study:

  • To systematically review the evolution of ESC devices.
  • To analyze data from studies utilizing ESC across various diseases.

Main Methods:

  • Searched electronic databases (MEDLINE, Google Scholar) up to February 2018.
  • Included search terms: "electrochemical skin conductance," "EZSCAN," and "Sudoscan."
  • Extracted and compared data from 37 included studies.

Main Results:

  • ESC values showed no significant changes with age or gender but varied widely between diseases.
  • Some disease-related ESC changes lacked biological plausibility.
  • 25 of 37 studies received manufacturer funding; extracted data conflicted with published normative values.

Conclusions:

  • Published ESC data raises concerns regarding its validity and biological plausibility.
  • Inconsistent normative values and lack of large-scale data challenge sensitivity and specificity claims.
  • Insufficient evidence supports ESC's utility in testing sudomotor or sensory nerve fiber function.