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Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
Published on: September 27, 2013
The Use of Biodegradable Nanoparticles for Tolerogenic Therapy of Allergic Inflammation
Charles B Smarr1,2, Stephen D Miller3
1Department of Microbiology-Immunology and Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Abstract:
Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.
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