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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Current Prevention and Treatment Options for NAFLD.

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  • 1Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, Hong Kong. wongv@cuhk.edu.hk.

Advances in Experimental Medicine and Biology
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Non-alcoholic fatty liver disease (NAFLD) management emphasizes lifestyle changes. While cardiovascular disease is the primary concern, targeted treatments are emerging for severe cases and potential future therapies for fibrosis.

Keywords:
non-alcoholic steatohepatitis; obeticholic acid; elafibranor; cenicriviroc; selonsertib

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Public Health

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition globally.
  • NAFLD is a significant factor in liver transplantation and hepatocellular carcinoma (HCC) development.
  • Cardiovascular disease is the leading cause of mortality in individuals with NAFLD.

Purpose of the Study:

  • To outline the prevention and management strategies for Non-alcoholic fatty liver disease (NAFLD).
  • To discuss current and future therapeutic interventions for NAFLD.
  • To highlight the role of lifestyle modifications and surgical options in NAFLD care.

Main Methods:

  • Review of current literature and clinical guidelines on NAFLD prevention and management.
  • Analysis of epidemiological data regarding NAFLD prevalence and outcomes.
  • Evaluation of pharmacological and surgical treatment options for NAFLD.

Main Results:

  • Healthy lifestyle interventions are fundamental for NAFLD prevention and management.
  • Pharmacological treatments are currently reserved for specific cases of non-alcoholic steatohepatitis (NASH).
  • Bariatric surgery shows favorable long-term effects on NAFLD histology in morbidly obese patients.

Conclusions:

  • Lifestyle modification is the primary strategy for NAFLD.
  • Future research is exploring anti-fibrotic agents for advanced NAFLD.
  • Bariatric surgery is a viable option for select obese patients with NAFLD.