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Updated: Feb 8, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Published on: February 28, 2017

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Deregulation of the Notch pathway as a common road in viral carcinogenesis

Elenaé Vázquez-Ulloa1,2, Marcela Lizano3, Marika Sjöqvist4

  • 1Programa de Maestría y Doctorado en Ciencias Bioquímicas, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Reviews in Medical Virology
|June 30, 2018
PubMed

Insights

Viral oncoproteins directly interact with the Notch pathway, influencing cell communication and potentially driving cancer development. Understanding these interactions is key to deciphering Notch

Area of Science:

  • Molecular Biology
  • Oncology
  • Virology

Background:

  • The Notch pathway is crucial for cell-cell communication in development and adulthood.
  • Deregulation of the Notch pathway is implicated in various diseases, notably cancer.
  • Viruses are responsible for a significant portion of cancer cases, with seven viral groups classified as oncogenic.

Purpose of the Study:

  • To review the direct interactions between viral oncoproteins and Notch pathway components.
  • To elucidate the role of these interactions in virus-associated cancers.
  • To understand the dual function of the Notch pathway as a potential activator or suppressor of neoplasia in viral oncogenesis.

Main Methods:

  • Literature review focusing on direct interactions between viral oncoproteins and Notch pathway elements.
  • Analysis of how these interactions alter Notch pathway function.
  • Synthesis of information on the impact of these interactions on cancer development.

Main Results:

  • Oncogenic viruses possess proteins that directly interact with Notch pathway components.
  • These viral proteins can manipulate the Notch pathway, affecting cell proliferation and differentiation.
  • The interactions can lead to the malignant transformation of cells.

Conclusions:

  • Direct interactions between viral oncoproteins and the Notch pathway are significant in virus-related cancers.
  • The Notch pathway exhibits context-dependent behavior, acting as either an activator or suppressor of cancer.
  • Further understanding of these molecular mechanisms is essential for therapeutic strategies against virus-associated malignancies.
Keywords:
EBVHBVHCVHPVHTLV-1KSHVMCPyVNOTCHcancer

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