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The regulatory role of microRNAs in angiogenesis-related diseases

Li-Li Sun1,2, Wen-Dong Li1, Feng-Rui Lei2

  • 1Department of Vascular Surgery, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Journal of Cellular and Molecular Medicine
|June 30, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of angiogenesis, a process vital for vascular health. Understanding miRNA roles offers new therapeutic targets for vascular diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNAs are crucial for angiogenesis, influencing cell proliferation, differentiation, apoptosis, migration, and tube formation.
  • Dysregulation of miRNAs in angiogenesis is implicated in various vascular diseases.

Purpose of the Study:

  • To review the intricate relationship between miRNAs and angiogenesis.
  • To highlight the role of miRNAs in the development and progression of vascular diseases.
  • To explore miRNA-based biomarkers for diagnosing and treating angiogenesis-related conditions.

Main Methods:

  • Literature review of studies on miRNAs and angiogenesis.
  • Analysis of miRNA regulatory mechanisms in angiogenesis.
  • Examination of clinical data on miRNA biomarkers for vascular diseases.

Main Results:

  • miRNAs significantly impact angiogenesis by controlling key cellular processes.
  • Aberrant miRNA expression is linked to numerous vascular pathologies, including cancer and cardiovascular disease.
  • miRNAs show promise as diagnostic, prognostic, and therapeutic agents in vascular disease.

Conclusions:

  • miRNAs are essential regulators of angiogenesis with significant clinical implications.
  • Targeting miRNAs presents a novel therapeutic avenue for managing vascular diseases.
  • Further research into miRNA-biomarkers can improve clinical outcomes for patients with vascular conditions.
Keywords:
angiogenesismicroRNAnon-coding RNAvascular disease

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