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In-vivo Raman spectroscopy: from basics to applications
Eliana Cordero1, Ines Latka1, Christian Matthäus1,2,3
1Leibniz-Institut für Photonische Technologien e.V., Germany.
Journal of Biomedical Optics
|June 30, 2018
Summary
Raman spectroscopy, a powerful tool for medical diagnostics, has advanced from lab research to in-vivo clinical use. This review details the technology, fiber optic probes, and clinical trials needed for successful integration into healthcare settings.
Area of Science:
- Biomedical Optics
- Spectroscopy
- Medical Technology
Background:
- Raman spectroscopy has been utilized in biological and medical fields for over 20 years.
- Technological advancements have facilitated the shift from ex-vivo to in-vivo applications.
- Clinical implementation requires specific technological developments and understanding, which can be challenging for new researchers.
Purpose of the Study:
- To review the instrumentation, parameters, and fiber optic probe designs for in-vivo Raman spectroscopy in clinical settings.
- To provide an overview of current technology, clinical trials, and future directions.
- To guide novice scientists in implementing this emerging technology in clinical environments.
Main Methods:
- Review of contemporary instrumentation and technological developments.
- Analysis of fiber optic probe designs for in-vivo applications.
- Overview of current clinical trials and applications.
Main Results:
- Matured instrumentation and statistical evaluation enable in-vivo examinations.
- Fiber optic probes are crucial for clinical implementation.
- Various tissue and disease types can be characterized using in-vivo fiber optic Raman probes.
Conclusions:
- Raman spectroscopy is transitioning into clinical practice, supported by technological progress.
- Further development is needed to fully integrate this technology for end-users.
- Fiber optic probes are key to realizing the potential of in-vivo Raman spectroscopy in diverse medical applications.
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