Neutrophils as myeloid-derived suppressor cells
Cathelijn E M Aarts1, Taco W Kuijpers1,2
1Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
European Journal of Clinical Investigation
|June 30, 2018
Summary
Mature neutrophils, initially known as immune defenders, can also suppress adaptive immunity. This review explores how these cells, including granulocytic-myeloid-derived suppressor cells (g-MDSCs), may be a single plastic cell type.
Area of Science:
- Immunology
- Cell Biology
Background:
- Neutrophils are key innate immune cells fighting pathogens.
- Recent findings reveal neutrophils can also suppress adaptive immunity, particularly in conditions like cancer.
- This immunosuppression is mediated by myeloid-derived suppressor cells (MDSCs).
Purpose of the Study:
- To review the immunosuppressive functions of circulating mature neutrophils.
- To explore the relationship between mature neutrophils and granulocytic-myeloid-derived suppressor cells (g-MDSCs).
- To investigate if neutrophils are a plastic cell type capable of switching functions.
Main Methods:
- Literature review focusing on MDSC activity in mature neutrophils.
- Analysis of cell morphology and surface marker expression.
- Examination of functional polarization of neutrophils.
Main Results:
- Myeloid-derived suppressor cells (MDSCs) include granulocytic (g-MDSCs) and monocytic populations.
- Mature neutrophils share characteristics with g-MDSCs, differing mainly in suppressive capacity.
- The plasticity of neutrophils suggests they may polarize from antimicrobial to immunosuppressive roles.
Conclusions:
- Circulating mature neutrophils exhibit myeloid-derived suppressor cell (MDSC) activity.
- Human g-MDSCs and neutrophils may represent a single, plastic cell type.
- Local conditions likely dictate whether neutrophils function as immune defenders or immunosuppressors.
Keywords:
myeloid-derived suppressor cells
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